Menstruation and Systemic Disease

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Abstract
MENSTRUATION is a complex process involving delicate and properly-timed relations between hypothalamus, pituitary gland, ovary and uterine endometrium. It is sometimes forgotten that normal menstrual function relates also to the thyroid and adrenal glands, liver, vascular system, nutritional status and emotional factors. It is the purpose of this paper to review the relation of disorders of menstruation to certain systemic diseases. With the exception of the work of Frank1 and of Rubin and Novak,2 no reviews of similar scope have been presented.General ConsiderationsWater and Electrolyte Balance in the Menstrual CycleAlthough the more prominent effects of estrogen and . . .