GROWTH HORMONE INCREASES PLASMA LEVELS OF INSULIN-LIKE GROWTH FACTOR (IGF-I) IN A TELEOST, THE GILTHEAD SEABREAM (SPARUS AURATA)
- 1 February 1989
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 120 (2) , R19-R21
- https://doi.org/10.1677/joe.0.120r019
Abstract
A heterologous radioimmunoassay (RIA) was applied for the determination of immunoreactive (IR)insulin-like growth factor (IGF-I) in a teleost, the gilthead seabream (Sparus aurata). Serial dilutions of the fish plasma gave a linear curve when added to constant amounts of 125I-labelled human IGF-I(53-70) and antiserum prepared against this fragment. The RIA was used to study the effect of GH on plasma levels of IR-IGF-I in S. aurata. A single injection of human recombinant GH (1 μg/g) resulted in a significant increase in IR-IGF-I at 29, 48 and 72 h, when compared with saline-injected fish. This novel observation suggests that in fish, as in mammals, circulating IGF-I levels are modulated by GH.This publication has 16 references indexed in Scilit:
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