SHOCK FOLLOWING VENOUS OCCLUSION OF A LEG

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Abstract
Nearly complete venous occlusion of a hind limb of the dog leads to shock which terminates fatally. This procedure offers a simple way of studying the course of shock and the utility of some of the proposed therapeutic agents to counteract shock. The mechanism is the marked loss of fluid into the leg, at first plasma and later whole blood, amounting from 4-6% of the body wt. This loss is brought about first by an increase in the capillary hydrostatic pressure of the occluded limb soon aggravated by loss of capillary permeability. These expts. support the view that the primary mechanism in shock is the local loss of fluid from the blood.

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