Determination of platinum in blood by adsorptive voltammetry
- 1 August 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 62 (15) , 1637-1640
- https://doi.org/10.1021/ac00214a020
Abstract
This work describes a sensitive method for the determination of platinum in blood, which can be used for determining the natural levels of platinum in human blood, for monitoring patients treated with platinum cytotoxic drugs, and for monitoring occupational exposure to these drugs and other platinum compounds. The method involves dry ashing of blood samples in a muffle furnace and determination of platinum by adsorptive voltammetric (AV) measurement of the catalytic reduction of protons by the platinum-formazone complex. The detection limit for a 100-.mu.L sample of blood is 0.017 .mu.g/L, with a recovery of 94% and a relative standard deviation of 7% at a platinum level of 1 .mu.g/L. By using this method, the natural levels of platinum in human blood were found to be in the range 0.1-2.8 .mu.g/L (median = 0.6 .mu.g/L). These results were verified by inductively coupled plasma mass spectrometry (ICP-MS) with blood prepared by wet ashing and using gold as an internal standard.This publication has 4 references indexed in Scilit:
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