Inhibitory Effect ofIsodonDiterpenoids on Growth and Mitochondrial Oxidative Phosphorylation in Lepidopterous Insects

Abstract
The diterpenes from the plants of the genus Isodon (Labiatae) exhibited a relatively specific growth inhibitory activity against lepidopterous larvae. The α-methylene cyclo- pentanone moiety (D-ring) was essential for this activity. In addition, these compounds strongly inhibited the oxidative phosphorylation in mitochondria isolated from silkworm midgut.