Major karyotypic abnormality in a child born to a woman with untreated malignant melanoma

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Abstract
The karyotype of a 7 mo. old child had 46 chromosomes, including 5 abnormal chromosomes in cultured lymphocytes. G-banding indicated the presence of reciprocal translocation products between chromosomes 1 and 7 and between chromosomes 4 and 15. A probable 3rd translocation involved the same chromosome 4p arm and 12q. All metaphases showed these changes. C-band markers and the presence of reciprocal exchange products indicated that the chromosome changes occurred in the zygote or a postzygotic cell of the child. The mother developed malignant melanoma while carrying the child but did not receive therapy before its birth. An undetected common agent was involved in the etiology of the mother''s tumor and the clastogenic change in the child''s chromosome.

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