Comparative Susceptibility of Yersinia enterocolitica, Eikenella corrodens, and Penicillin-Resistant and Penicillin-Susceptible Streptococcus pneumoniae to β-Lactam and Alternative Antimicrobial Agents

Abstract
The antimicrobial susceptibilities were determined for 14 strains of Yersinia enteroco/itica, 28 strains of Eikenella corrodens, 10 strains of penicillin-resistant Streptococcus pneumoniae, and 10 strains of penicillin-susceptible S. pneumoniae. Y. enteroco/itica was found to be susceptible to the aminoglycosides tested and to chloramphenicol, moxalactam, cefoperazone, and cefotaxime but resistant to ampicillin and variably susceptible to carbenicillin, cefoxitin, and cefazolin. On a weight basis, cefotaxime and moxalactam were the most active agents against E. corrodens. Most strains of E. corrodens were resistant to the aminoglycosides tested: gentamicin, tobramycin, kanamycin, and amikacin. Penicillin-resistant S. pneumoniae was most susceptible to cefotaxime and moxalactam. Cefotaxime was consistently active against all tested strains of Y. enteroco/itica, E. corrodens, and penicillin-resistant S. pneumoniae, three unusual but clinically significant pathogens.

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