Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
Top Cited Papers
Open Access
- 29 January 2004
- journal article
- review article
- Published by Springer Nature in The EMBO Journal
- Vol. 23 (3) , 483-488
- https://doi.org/10.1038/sj.emboj.7600061
Abstract
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions.Keywords
This publication has 48 references indexed in Scilit:
- Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteasesNature Cell Biology, 2000
- Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with InhibitorScience, 2000
- Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processingNature, 2000
- Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane ProteinsMolecular Cell, 2000
- BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor proteinProceedings of the National Academy of Sciences, 2000
- Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1Nature Cell Biology, 2000
- Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1Nature Cell Biology, 2000
- Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1Nature, 2000
- Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activityNature, 1999
- Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinNature, 1998