Evaluation of Acetaminophen, Propoxyphene, and Their Combination in Office Practice

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Abstract
Thirty-two patients with chronic painful disease treated in office practice willingly participated in a double-blind, crossover analgesic study. They were informed about (1) the medications--placebo, 650 mg acetaminophen, 100 mg propoxyphene napsylate, and the combination of the two active drugs; (2) the regimen--four to six single-tablet doses per day for two days, crossover; (3) the reporting system--estimates of pain intensity and scores for other symptoms to be reported daily by telephone; and (4) return of the unused medication on the next office visit. In comparison to placebo, propoxyphene provided statistically significant analgesia, but acetaminophen did not. Significant adverse effects were not present with any test drug when compared to test placebo.

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