Experimental liver necrosis in rats: 2. The levels of glutathione and ascorbic acid in livers subjected to acute circulatory congestion in relation to the levels found in dietetic liver necrosis

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Abstract
The composition of liver lobes rendered necrotic by subjection to acute circulatory congestion was investigated and compared with that of necrotic livers of dietary origin. The levels of reduced glutathione, ascorbic acid, non-protein and total N, water and glycogen were found to be similar in both types of necrosis. The composition of amputated liver lobes left to autolyze in the abdominal cavity resembled that of necrotic livers, but an excised lobe autolyzing in vitro showed no resemblance to necrotic livers. As a result of the findings, the suggestion is put forward that the levels of glutathione and ascorbic acid found in dietetic liver necrosis could be the result of changes occurring in a dead or dying liver left in the living body, and were not specific consequences of the dietetic lesion.