THERAPY OF VIRILIZING ADRENAL HYPERPLASIA WITH HYDROCORTISONE ACETATE
- 23 April 1955
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 157 (17) , 1479-1481
- https://doi.org/10.1001/jama.1955.02950340009003
Abstract
The use of cortisone therapy of adrenal hyperplasia with virilism, as introduced by Wilkins in 1950,1is one of the most gratifying experiences in medicine. It enables one to convert a virilized, amenorrheic, sterile woman into a woman potentially capable of conception. Prior to the present, the best therapy available appeared to be the intramuscular injection of cortisone acetate two or three times a week.2We are not aware of anyone who has successfully spaced injections with the currently available preparations of cortisone acetate at intervals greater than four days. Prader3used macrocrystalline cortisone in dosages of 800 mg. every 30 days with good results. Somewhat larger doses are required orally and must be given in divided doses three or four times daily. In general, oral therapy has been found by various groups to be less effective than intramuscular therapy.4In addition, as pointed out byKeywords
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