Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene
- 8 June 2003
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 34 (3) , 261-262
- https://doi.org/10.1038/ng1171
Abstract
MicroRNAs (miRNAs) are an abundant class of RNAs that are ∼21–25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.Keywords
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