Static and dynamic imaging with indium-111 labelled Bleomycin in the localization of squamous cell neoplasia

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Abstract
Fifty-two cases of squamous cell carcinoma were studied using 111In labeled bleomycin. The overall accuracy of localization by static imaging alone was 80%. Detection of lung and gynecological tumors was most consistent, while eophageal tumors were the most commonly missed. Imaging within a few hours of administration of the radiopharmaceutical was as effective as imaging at the recommended time of at least 24 h. Inflammatory lesions giving false positive scans could be differentiated from tumor tissue by dynamic imaging. Maximum activity occurred in tumor tissue 10 min after the peak for normal tissue. This difference was used to improve the detection of known tumors to 90%.