Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.
Open Access
- 1 November 1990
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 10 (11) , 6073-6078
- https://doi.org/10.1128/mcb.10.11.6073
Abstract
In cells transformed by v-raf, an oncogenic counterpart of the serine/threonine kinase Raf-1, regulatory elements of the c-fos promoter were active under conditions of cell growth or stimulation for which they were inactive in untransformed control cells. This suggests that v-raf transforms by deregulating transcription of early response genes.This publication has 37 references indexed in Scilit:
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