Dynamics of Regression of Right Ventricular Hypertrophy in Rats with Hypoxic Pulmonary Hypertension

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Abstract
Normobaric hypoxia caused a significant increase in right:left ventricular weight ratio in rats, a reliable indicator of hypertrophy of the right ventricle, after only 1 wk of intermittent hypoxic confinement. Seven days after termination of a 4 wk hypoxic exposure the right:left ventricular weight ratio was significantly lower compared to the values immediately after hypoxic treatment. Eight weeks of sojourning in a normoxic environment were not sufficient to normalize the right ventricular systolic pressure and right:left ventricular weight ratio. Changes in right ventricular mass in the rat is a fast reaction to changes in pressure load.