PLASMA CORTICOSTERONE IN RATS AFTER ELECTROCHEMICAL STIMULATION OF THE OLFACTORY BULBS
- 1 August 1972
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 54 (2) , 353-354
- https://doi.org/10.1677/joe.0.0540353
Abstract
The effect of stimulation and lesions of the extrahypothalamic neural structures on corticotrophin (ACTH) secretion has been widely investigated (Mangili, Motta & Martini, 1966; Rubin, Mandell & Crandall, 1966; Redgate, 1970). Palma, Perassi & Loyber (1971) found that electrochemical stimulation of the olfactory bulbs in rats produced depletion of adrenal ascorbic acid, while their resection (Loyber, Lecuona, Palma & Perassi, 1971) decreased the urinary 17-oxosteroids. Plasma corticosterone levels were therefore investigated in rats to determine the effect of olfactory bulb stimulation on ACTH secretion. White, female, virgin rats (150–180 g) bred in our institute were used. They were all kept under the same conditions and divided into three groups subjected to the following: (a) bilateral electrochemical stimulation of olfactory bulbs; (b) bilateral electrochemical stimulation of parietal cerebral cortex; (c) sham stimulation of olfactory bulbs. Electrochemical stimulation was effected by a stainless steel electrode, 0·3 mm diameter, passing 1 mA, d.c.Keywords
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