Epstein-Barr Virus-Induced Viral and Soluble Complement-Fixing Antigens in Burkitt Lymphoma Cell Cultures
- 1 July 1970
- journal article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 134 (3) , 748-751
- https://doi.org/10.3181/00379727-134-34875
Abstract
Epstein-Barr virus-infected Burkitt lymphoma cell cultures contain viral (V) and virus-induced, nonsedimentable, soluble (S) antigens which react in complement-fixation tests with certain human and subhuman primate sera containing antibodies to the V antigen. An apparently related soluble antigen was demonstrated in concentrated cell-free fluids of virus-free Raji cell cultures. Serologic evidence is presented to relate S antigens to EBV infections in man and subhuman primates. The release of S antigen by virus-free Raji and other lymphoid cell lines suggests the possible presence of a portion of the viral genome in some of these cells. Data on the physical properties of V and S antigens are presented.Keywords
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