Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum

1 January 2000

journal article
research article
Published by Taylor & Francis in Xenobiotica

Vol. 30 (6) , 609-617
https://doi.org/10.1080/004982500406435

Abstract

1. Resveratrol, a polyphenolic compound present in grapes and wine, has beneficial effects against cancer and protective effects on the cardiovascular system. It is present in the diet, and the hepatic and duodenal sulphation might limit the bioavailability of this compound. The aim was to study the sulphation of resveratrol in the human liver and duodenum. 2. A simple and reproducible radiometric assay for resveratrol sulphation was developed. It employed 3'-phosphoadenosine-5'-phosphosulphate-[³⁵

Keywords

This publication has 15 references indexed in Scilit:

Differential Effects on Growth, Cell Cycle Arrest, and Induction of Apoptosis by Resveratrol in Human Prostate Cancer Cell Lines
Experimental Cell Research, 1999
Resveratrol, a Polyphenolic Compound Found in Wine, Inhibits Tissue Factor Expression in Vascular Cells
Arteriosclerosis, Thrombosis, and Vascular Biology, 1999
Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium
The American Journal of Clinical Nutrition, 1998
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
Proceedings of the National Academy of Sciences, 1997
Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning and structural characterization
Pharmacogenetics, 1996
Method To Assay the Concentrations of Phenolic Constituents of Biological Interest in Wines
Analytical Chemistry, 1996
Methods of Determining Plasma and Tissue Binding of Drugs
Clinical Pharmacokinetics, 1992
Human platelet phenolsulphotransferase M and P: substrate specificities and correlation with in vivo sulphoconjugation of paracetamol and salicylamide.
British Journal of Clinical Pharmacology, 1983
Phenolsulphotransferase in human tissue: Radiochemical enzymatic assay and biochemical properties
Clinica Chimica Acta; International Journal of Clinical Chemistry, 1980
Rat brain phenolsulfotransferase—partial purification and some properties
Biochimica et Biophysica Acta (BBA) - Enzymology, 1973