Reduced Gray Matter Volume in Schizophrenia

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Abstract
NEUROANATOMICAL studies in schizophrenia indicate volume reduction and increased cerebrospinal fluid (CSF).1,2 Magnetic resonance imaging (MRI) enables segmentation of parenchyma into gray matter (GM) and white matter (WM) and permits evaluation of all major intracranial compartments related to cytoarchitecture and connectivity, including GM (the somatodendritic compartment of neurons [cortical and deep]), WM (the axonal compartment of myelinated connecting fibers), and CSF.3-6 Interpretation of findings for specific structures depends on neuroanatomical measures for the entire supertentorium; these can contribute to understanding aberrant developmental processes in schizophrenia.