Somatic Mutation and Aging
- 1 November 1998
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 854 (1) , 20-22
- https://doi.org/10.1111/j.1749-6632.1998.tb09888.x
Abstract
A key prediction of the somatic mutation theory of aging is that there is an invariant relationship between life span and the number of random mutations. A number of studies at a number of gene loci have shown that somatic mutations of a variety of types accumulate with age. Dietary restriction, which prolongs life span, results in slowed accumulation of HPRT mutants in mice. Conversely, senescence‐accelerated mice, which have been bred to have a shortened life span, show accelerated accumulation of somatic mutations.Keywords
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