Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias

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• δ-Aminolevulinic Acid Synthetase and the Control of Heme and Chlorophyll Synthesis**This review was aided by grants from the National Institutes of Health, GM-04922, and from the National Science Foundation, GB-6818.††Abbreviations: AA, aminoacetone; AIA, allyl isopropyl acetamide (an inducing chemical); AIP, acute intermittent porphyria; ALA, δ-aminolevulinic acid; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; ELB, early labeled bilirubin; Heme, ferrous or ferric iron protoporphyrin; Hemin, hemin chloride or ferric iron protoporphyrin chloride; PBG, porphobilinogen; NuTP, nucleoside triphosphate.
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