Genetic Component in Rat Mammary Carcinogenesis

Publisher Website
Google Scholar
Abstract
Five genetically defined strains of female rats were exposed to whole-body radiation with a single dose of 50 rad of fission neutrons. After 1 yr, 56% of the Long-Evans and Sprague-Dawley strains showed at least 1 mammary tumor; 25-29% of the Buffalo and Fischer-344 strains and only 5% of the Wistar-Lewis strain had palpable mammary tumors. Only 1 tumor was found among 73 unirradiated controls during the 1-yr observation period. Approximately 2/3 of 50 mammary neoplasms analyzed pathologically were adenofibromas and fibroadenomas; 1/3 were adenocarcinomas. The Kaplan-Meier method of life table analysis was used to deal with the problem of intercurrent mortality. A genetic factor seems evident in rat mammary tumorigenesis following exposure to fission neutrons.

This publication has 0 references indexed in Scilit: