Endocrine‐metabolic response to abdominal aortic surgery: A randomized trial of general anesthesia versus general plus epidural anesthesia
- 1 September 1993
- journal article
- clinical trial
- Published by Wiley in World Journal of Surgery
- Vol. 17 (5) , 601-606
- https://doi.org/10.1007/bf01659119
Abstract
The influence of epidural anesthesia on the endocrine-metabolic response following abdominal aortic reconstruction was studied in a prospective randomized trial. Cortisol and catecholamine responses and nitrogen balance were measured in two groups of five patients receiving general anesthesia only (group 1) or general anesthesia combined with epidural bupivacaine (group 2). The study lasted from preoperatively until the first postoperative day. At 2100 hours on the day of surgery serum cortisol concentrations were higher in group 1 than in group 2 (1.41 versus 0.82 μmol/L; p* hora, p<0.01). La excreción urinaria intraoperatoria de epinefrina y la excreción postoperatoria de norepinefrina aparecieron significativamente más altas en el Grupo 1 que en el Grupo 2. No se registraron diferencias en la excreción urinaria de cortisol libre ni en el balance acumulado de nitrógeno. Aunque el número de pacientes fue limitado y el nivel del bloqueo sensorial no fue determinado perioperatoriamente, el presente estudio sugiere que la anestesia epidural atenúa la respuesta de estrés en la cirugia aórtica.Keywords
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