Tremorgenic Toxin from Penicillium verruculosum
Open Access
- 1 January 1972
- journal article
- research article
- Published by American Society for Microbiology in Applied Microbiology
- Vol. 24 (2) , 248-250
- https://doi.org/10.1128/aem.24.2.248-250.1972
Abstract
A new mycotoxin that produces severe tremors and acute toxicity when administered orally or intraperitoneally (ip) to mice and 1-day-old cockerels was obtained from a strain of Penicillium verruculosum Peyronel isolated from peanuts. The ip 50% lethal dose (LD50) of this tremorgen was 2.4 mg/kg in mice and 15.2 mg/kg in chickens. Orally administered LD50 values for the toxin were 126.7 mg/kg in mice and 365.5 mg/kg in chickens. The trivial name “verruculogen” is proposed for this tremorgenic mycotoxin. Physical and chemical characteristics of the mycotoxin are described.Keywords
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