Possible bioactive conformations of α‐melanotropin
- 21 May 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 170 (2) , 315-320
- https://doi.org/10.1016/0014-5793(84)81335-6
Abstract
By comparing the results of energy calculation for α‐MSH and its semirigid analogues , , and , a detailed description of two possible bioactive conformations for the ‘specific’ central site of α‐MSH6–9 is proposed representing variants of chain‐reversal structure. A possible explanation of the rise in melanotropic activity of the latter two semirigid analogues is presented.Keywords
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