Ectromelia Virus Multiplication in Mouse Liver
Open Access
- 1 June 1954
- journal article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 10 (3) , 345-352
- https://doi.org/10.1099/00221287-10-3-345
Abstract
SUMMARY: The multiplication of ectromelia virus in mouse liver cells has been studied using intravenous inocula of 106 to 1010 LD50 doses. About 30% of this virus is found in the liver in 5 min., and most of this disappears as infective virus in the next hour. After a lag period, the length of which depends on the number of LD50 doses/cell which initiated the infection, the virus titre increases again to the 5 min. level. Subsequently, steps of multiplication, each separated by a lag period, occur within each cell. The efficiency of virus multiplication over the range tested is independent of the infecting dose.Keywords
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