Cytoskeletal Tumor Suppressors That Block Oncogenic RAS Signaling
- 1 December 1999
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 886 (1 ANTICANC) , 48-57
- https://doi.org/10.1111/j.1749-6632.1999.tb09399.x
Abstract
Several distinct peptides or drugs that block the Rho family GTPases-mediated pathways were found to suppress RAS-induced malignant phenotype. They include (1) C3 enzyme that selectively inactivates Rho, (2) ACK42, a peptide that blocks the interaction of CDC42 with its effectors such as ACKs, (3) PAK18, a peptide that blocks the activation of PAK and membrane ruffling, and (4) actin-binding drugs, chaetoglobosin K (CK) and MKT-077, that block membrane ruffling by capping and bundling actin filaments, respectively.Keywords
This publication has 20 references indexed in Scilit:
- The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformationOncogene, 1999
- Trojan peptides: the penetratin system for intracellular deliveryTrends in Cell Biology, 1998
- SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathwayOncogene, 1997
- A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryosCurrent Biology, 1997
- Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsCell, 1995
- An essential role for Rac in Ras transformationNature, 1995
- Tensin: A potential link between the cytoskeleton and signal transductionBioEssays, 1994
- A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42Nature, 1993
- Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitroThe Journal of cell biology, 1982
- Chaetoglobosin K: a new plant growth inhibitor and toxin from Diplodia macrosporaJournal of Agricultural and Food Chemistry, 1980