Glucose-6-Phosphate Dehydrogenase Deficiency and Falciparum Malaria *

Abstract
Summary Investigations of the duration of the prepatent period and of the early clinical course of falciparum malaria (McLendon strain) were conducted with 16 non-immune American Negro men. Eight of the men were glucose-6-phosphate dehydrogenase (G6PD)-deficient and 8 were not. The investigations did not disclose evidence supporting the hypothesis that G6PD deficiency confers a biologic advantage against falciparum malaria.

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