Potentiating Effect of Iproniazid on Action of Some Sympathicomimetic Amines.
- 1 October 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 87 (1) , 218-220
- https://doi.org/10.3181/00379727-87-21339
Abstract
Several sympathicomimetic amines produce convulsions in guinea pigs. Pretreatment with 1-isonicotinyl-2-isopropyl hydrazine (iproniazid) potentiates the effect of phenylethylamine and tyramine, but not of ephedrine and alpha-methylphenylethylamine. Isoniazid is less effective. The onset of the toxic syndrome is accompanied by a marked increase of body temperature. The results are explained by the blocking of monoamine oxidase by iproniazid.Keywords
This publication has 4 references indexed in Scilit:
- CONVULSANT EFFECTS OF ISONIAZIDJAMA, 1953
- In vivo Inhibition of Liver and Brain Monoamine Oxidase by 1-Isonicotinyl-2-Isopropyl Hydrazine.Experimental Biology and Medicine, 1952
- Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymesCellular and Molecular Life Sciences, 1952
- AMINE OXIDASE AND AMINE METABOLISM1952