Hemagglutination by Botulinal Toxin

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Abstract
Type A botulinal toxin causes agglutination of chicken, guinea pig, rabbit, sheep and human red blood cells. The agglutination is not accompanied by evidence of adsorption of toxin by the agglutinated red cells. The agglutination is inhibited specifically by type A antitoxin. Once agglutination has occurred it is not reversed by the addition of antitoxin in the case of chicken red cells. Agglutinated chicken red cells when freed of toxin tend to remain agglutinated while sheep cells are more readily dispersed. Sheep cells were more sensitive than chicken cells to the influence of temp. With both types of cells the effect of temperature was relatively independent of previous temp. exposures of cell-toxin mixtures. Lower temp. gave higher hemagglutination titres.

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