Mucocutaneous diseases in drug addicts with or without HIV infection. A case-control study
- 1 March 1994
- journal article
- research article
- Published by Springer Nature in Infection
- Vol. 22 (2) , 77-80
- https://doi.org/10.1007/bf01739008
Abstract
A case-control study was performed to evaluate the prevalence of mucocutaneous diseases in 106 male drug addicts (age 21–38 years) with or without HIV infection. A mucocutaneous disease was recorded in ten out of 64 HIV-negative and in 20 of 42 HIV-positive patients (OR=4.9; p<0.01). Some mucocutaneous diseases were present in similar proportions in both groups (i. e. fungal skin lesions), while others were typically present only in HIV-positive patients. Stratification for possible confounding factors, such as years of drug addiction and number of sexual partners, confirmed that HIV infection is the main risk factor for mucocutaneous disease. Stratification according to the number of CD4-positive cells showed that the more advanced the HIV disease, the more frequently mucocutaneous disease was present (p=0.02). The study demonstrates that many, but not all, mucocutaneous diseases are associated with HIV infection. Zur Bestimmung der Prävalenz von mukokutanen Krankheiten wurde bei 106 männlichen Drogenabhängigen (Alter 21 bis 38 Jahre) mit oder ohne HIV-Infektion eine Fall-Kontroll-Studie durchgeführt. Bei zehn der 64 HIV-negativen und 20 der 42 HIV-positiven Patienten wurde eine mukokutane Krankheit gefunden (OR=4,9; p<0,01). Einige mukokutane Krankheiten wiesen in beiden Gruppen ein ähnliches Vorkommen auf (zum Beispiel Pilzinfektionen der Haut), andere fanden sich typischerweise nur bei HIV-Infizierten. Eine Stratifikation nach möglichen Einflußfaktoren wie Jahr der beginnenden Drogenabhängigkeit und Zahl der sexuellen Partner bestätigte, daß die HIV-Infektion der Hauptrisikofaktor für mukokutane Erkrankungen ist. Die Stratifikation nach der Zahl CD4-positiver Zellen zeigte, daß sich mit fortschreitender HIV-Krankheit zunehmend mukokutane Erkrankungen einstellen (p=0,02). Die Studie ließ erkennen, daß viele, aber nicht alle mukokutanen Erkrankungen mit der HIV-Infektion assoziiert sind.Keywords
This publication has 15 references indexed in Scilit:
- Clinical features of inflammatory dermatoses in human immunodeficiency virus type 1 disease and their correlation with Walter Reed stageJournal of the American Academy of Dermatology, 1993
- Herpes Zoster and Human Immunodeficiency Virus InfectionThe Journal of Infectious Diseases, 1992
- Molluscum contagiosum in patients with human immunodeficiency virus infectionJournal of the American Academy of Dermatology, 1992
- The spectrum of nail disease in patients with human immunodeficiency virus infectionJournal of the American Academy of Dermatology, 1992
- Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS)Journal of the American Academy of Dermatology, 1987
- Herpes zoster: A possible early clinical sign for development of acquired immunodeficiency syndrome in high-risk individualsJournal of the American Academy of Dermatology, 1986
- Fungal Infections in Patients with AIDS and AIDS-related ComplexScandinavian Journal of Infectious Diseases, 1986
- Seborrheic dermatitis in patients with acquired immunodeficiency syndromeJournal of the American Academy of Dermatology, 1985
- Skin disease in homosexual patients with Acquired Immune Deficiency Syndrome (AIDS) and lesser forms of human T cell Leukaemia Virus (HTLV III) diseaseClinical and Experimental Dermatology, 1985
- Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1984