Serum concentrations of sICAM‐1, sE‐, sP‐ and sL‐selectins in patients with Schistosoma mansoni infection and association with disease severity

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Abstract
Increased serum concentrations of soluble intercellular adhesion molecule‐1 (sICAM‐1, CD54) and of soluble E‐ (CD62E), but not soluble P‐ (CD62P) and L‐ (CD62 L) selectins, were detected in Malagasy patients living in an hyperendemic focus of Schistosoma mansoni. Levels of sICAM‐1 remained elevated for several months after treatment with praziquantel. Serum levels of ICAM‐1, but not of other markers, were significantly correlated with the disease severity, as indicated by ultrasonographical data, and with some circulating fibrosis markers (at least hyaluronic acid). sICAM‐1 level may reflect endothelial inflammatory reactions, probably harmful, in the liver and may be useful for monitoring morbidity evolution in schistosomiasis mansoni.