P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide
- 1 July 2004
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 21 (7) , 1294-1302
- https://doi.org/10.1023/b:pham.0000033018.97745.0d
Abstract
Purpose. The isolation of hepatocytes from intact liver involves collagenase digestion of the tissue, resulting in loss of cell polarization and functional vectorial excretion. These studies examined...Keywords
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