Reversal of Experimental Endotoxin Shock with a Combination of Aldosterone and Metaraminol

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Abstract
Lethal shock was established in 55 adult mongrel dogs with a standardized dose of Escherichia coli endotoxin. The shock could not be reversed with aldosterone or metaraminol when either was used alone. However, dogs given 0.1 mg of aldosterone required approximately one-fiftieth the dose of metaraminol necessary to maintain systemic pressure, compared to the use of metaraminol alone. This action of aldosterone was about 7 times more pronounced than that obtained with hydrocortisone. The nature of the contributing effect of steroid to the pressor activity of metaraminol and to the increased survival rate is not known.

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