PARTICIPATION OF ANGIOTENSIN-II IN LEARNING AND MEMORY .3. INTERACTIONS OF ANGIOTENSIN-II WITH GABAERGIC DRUGS

  • 1 April 1987
    • journal article
    • research article
    • Vol. 9  (4) , 205-208
Abstract
The experiments were carried out on male albino rats trained and tested for retention (24 hr later) in a shuttle-box. Angiotensin II (AT II) 0.10 .mu.g intracerebroventricularly (i.c.v.), gamma-aminobutyric acid (GABA) 100 .mu.g i.c.v., bicuculline 0.5 and 1.0 mg/kg intraperitoneally (i.p.), and picrotoxin 0.5 and 1.0 mg/kg i.p. were administered independently or in combinations immediately after training. AT II was found to improve retention. GABA also facilitated retention. Combination of AT II + GABA potentiated the memory-improving effect of AT II. Bicuculline and picrotoxin at a dose of 0.5 mg/kg did not affect retention, while at a dose of 1.0 mg/kg they improved it. Combinations of AT II + bicuculline (0.5 mg/kg) and AT II + picrotoxin (0.5 mg/kg) abolished the retention-improving effect of AT II. Bicuculline (0.5 mg/kg) or picrotoxin (0.5 mg/kg) abolished the retention-facilitating effect of the combination of AT II + GABA as well as the potentiating action of GABA on the memory effect of AT II. These results suggest the participation of GABergic transmission in the CNS in the mechanisms of the long-term memory-improving effect of AT II.

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