REVERSAL OF THE DECIDUAL-INHIBITING EFFECT OF RELAXIN BY AN INACTIVE DERIVATIVE

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Abstract
Relaxin preparations, isolated from the ovaries of pregnant sows, have previously been shown to inhibit the formation of decidua in the uteri of ovariectomized, pseudopregnant rats treated with progesterone. This effect has been employed to study the interaction of an inactive derivative and the native hormone. When an excess of thioglycollate- or mercaptoethanol-inactivated relaxin is administered simultaneously with native relaxin, the inhibitory effect of the latter is nearly completely abolished. Preparations from the ovaries of non-pregnant sows, of low relaxin content, have a similar effect. It is suggested that the ability to inhibit the effects of a protein hormone may be shared by naturally-occurring proteins structurally related to the native hormone.

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