ANTI-LYMPHOCYTE GLOBULIN AND ADRENAL-STEROIDS IN THE TREATMENT OF MULTIPLE-SCLEROSIS - SHORT REPORT BASED ON 7 CASES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 58  (4) , 339-343
Abstract
A therapeutic trial of antilymphocyte globulin (ALG) combined with dexamethasone was carried out in 7 patients with chronic, relapsing multiple sclerosis. ALG was given in daily doses of 0.25-0.5 g on the weekdays over 1 to 2 mo. Total doses of ALG ranged from 12.5-17.7 g. Follow-up made after 1 yr showed that 2 had no deterioration and 2 became worse in the tolerant group; 2 showed no deterioration and 1 revealed fatal progression in the non-tolerant group. The treatment proved to be toxic in 3 patients. ALG probably enhances anti-inflammatory activity of adrenal steroids in some patients, but does not seem to change the natural course of the disease.

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