CNS Gene Encoding Astrotactin, Which Supports Neuronal Migration Along Glial Fibers
- 19 April 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5260) , 417-419
- https://doi.org/10.1126/science.272.5260.417
Abstract
Vertebrate central nervous system (CNS) histogenesis depends on glia-guided migration of postmitotic neurons to form neuronal laminae. Previous studies have established that the neuronal protein astrotactin functions in murine cerebellar granule cell migration in vitro. The gene encoding astrotactin predicts a protein with three epidermal growth factor repeats and two fibronectin type III repeats. Astrotactin messenger RNA is expressed in postmitotic neuronal precursors in the cerebellum, hippocampus, cerebrum, and olfactory bulb, where migration establishes laminar structures. Fab fragments of antibodies to a recombinant astrotactin peptide blocked migration of cerebellar granule neurons in vitro along astroglial fibers. Transfection of astrotactin complementary DNA into 3T3 cells indicated that astrotactin acts as a ligand for neuron-glia binding during neuronal migration.Keywords
This publication has 14 references indexed in Scilit:
- A protein related to extracellular matrix proteins deleted in the mouse mutant reelerNature, 1995
- Structure/function studies of lin-12/Notch proteinsCurrent Opinion in Genetics & Development, 1994
- The role of migration in central nervous system neuronal developmentCurrent Opinion in Neurobiology, 1993
- Antibodies that recognize astrotactin block granule neuron binding to astrogliaNeuron, 1990
- The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activityCell, 1990
- Adhesion molecules and the hierarchy of neural developmentNeuron, 1988
- The solution structure of human epidermal growth factorNature, 1987
- Time of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysisJournal of Comparative Neurology, 1973
- Mode of cell migration to the superficial layers of fetal monkey neocortexJournal of Comparative Neurology, 1972
- Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesusJournal of Comparative Neurology, 1971