Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.

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Abstract
The ability of female mice to rapidly reject syngeneic male skin grafts is largely determined by dominant genes in the IB region of the H-2b haplotype. The ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region of the H-2b haplotype, or by complementary genes in the IC region of some other haplotypes. It seems that H-2-restricted anti-H-Y cytotoxic T [thymus-derived] cells are not responsible for the rejection of syngeneic male skin grafts.