Studies on positive inotropic agents. II. Synthesis of (4-substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone derivatives.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (2) , 682-693
- https://doi.org/10.1248/cpb.34.682
Abstract
Many (1-piperazinylcarbonyl)-2(1H)-quinolinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. Among them, 3,4-dihydro-6-[4-(3-oxo-3-phenylpropyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIj) and 3,4-dihydro-6-[4-(4-oxo-4-phenylbutyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIl) were found to have potent activity.This publication has 1 reference indexed in Scilit:
- Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one].Circulation Research, 1979