Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function
Open Access
- 23 November 1995
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 333 (21) , 1386-1391
- https://doi.org/10.1056/nejm199511233332104
Abstract
Insulin, the central hormone controlling the utilization of fuel, is initially synthesized in pancreatic beta cells as its relatively inactive precursor, proinsulin. A series of enzymes that process prohormones act on proinsulin to produce mature insulin and C peptide. Abnormalities in the secretory products of beta cells are a rare but well-documented cause of impairment in glucose tolerance and hyperinsulinemia.1Keywords
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