Interference Between Lymphocytic Choriomeningitis and Rauscher Leukemia in Mice2

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Abstract
In a series of 10 independent experiments, performed on 314 adult and 105 newborn BALB/c mice, preinoculation with lymphocytic choriomeningitis (LCM) virus induced a significant protection against the leukemic disease due to infection with Rauscher virus. This protection was evidenced by lower incidence of leukemia, marked prolongation of incubation period, and delayed mortality. A significant proportion of LCM-pretreated animals remained free of leukemia symptoms for their lifespan. The protection was effective in adult mice when LCM virus was inoculated 1 to 5 days before Rauscher virus, being most effective when done 1 or 2 days in advance. In newborn mice the shielding effect of LCM infection persisted longer. It is concluded that concomitant infection with LCM and Rauscher viruses represents a working model demonstrating an efficient and sparing interference by a nonlethal and even asymptomatic viral infection with the development of usually fatal malignancy induced by an oncogenic virus.

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