Mechanism of Epinephrine Enhancement of Lidocaine-induced Skeletal Muscle Necrosis
- 1 May 1982
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 61 (5) , 686-690
- https://doi.org/10.1177/00220345820610051301
Abstract
Skeletal muscle damage produced in rats by 2% lidocaine in combination with agents that mimic or modify actions of epinephrine was assessed histologically. Only drugs producing vasoconstriction- epinephrine, phenylephrine, and felypressin — significantly augmented lidocaine myotoxicity. This potentiation was in direct relation to each drug's ability to retard absorption of the local anesthetic from its injection site.This publication has 9 references indexed in Scilit:
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