Efficacy and safety of a new Botulinum Toxin Type A free of complexing proteins in the treatment of blepharospasm
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- 15 June 2005
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 113 (3) , 303-312
- https://doi.org/10.1007/s00702-005-0323-3
Abstract
NT 201 is a new development of Botulinum Toxin Type A free of complexing proteins. In this double-blind Phase III trial, we compared the efficacy and safety of NT 201 and BOTOX® in patients suffering from blepharospasm. Of 304 enrolled patients, 300 patients received study medication (intent-to-treat population), and 256 patients completed the study as planned (per-protocol population). At baseline, patients received a single injection of NT 201 or BOTOX® (≤35 units per eye). No significant differences were found between NT 201 and BOTOX® for all efficacy and safety variables three weeks after injection. Both the NT 201 and the BOTOX® group showed a decrease in the Jankovic Rating Scale (JRS) sum score signifying an improvement in the symptoms of blepharospasm during this time period. These data show that NT 201* is an effective and safe treatment for patients suffering from blepharospasm.Keywords
This publication has 28 references indexed in Scilit:
- Efficacy and tolerability of a botulinum toxin type A free of complexing proteins (NT 201) compared with commercially available botulinum toxin type A (BOTOX°) in healthy volunteersJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 2004
- Botulinum toxin type A therapy for blepharospasmCochrane Database of Systematic Reviews, 2004
- Clinical presentation and management of antibody-induced failure of botulinum toxin therapyMovement Disorders, 2004
- Low-Dose Treatment of Cervical Dystonia, Blepharospasm and Facial Hemispasm with Albumin-Diluted Botulinum Toxin Type A under EMG GuidanceEuropean Neurology, 2000
- Treatment choices of 119 patients with hemifacial spasm over 11 yearsClinical Neurology and Neurosurgery, 1996
- Pretarsal application of botulinum toxin for treatment of blepharospasm.Journal of Neurology, Neurosurgery & Psychiatry, 1995
- Prevalence of focal dystonias in the western area of Tottori Prefecture in JapanMovement Disorders, 1995
- Development of resistance to botulinum toxin type A in patients with torticollisMovement Disorders, 1994
- Abnormal eye movements in blepharospasm and involuntary levator palpebrae inhibitionBrain, 1994
- Treatment of Blepharospasm with High Dose Brow Injection of Botulinum ToxinOphthalmic Plastic & Reconstructive Surgery, 1987