Chromium 51 EDTA/technetium 99m MDP plasma ratio to measure total skeletal function

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Abstract
A method is described for the quantitation of total skeletal activity during bone scans. The method requires a single plasma sample only, taken at the time of imaging. The ratio of % injected dose of 51Cr EDTA to that of 99mTc MDP [methylenediphosphonate] is calculated from this sample following combined injection of the 2 radiopharmaceuticals. The 51Cr EDTA level corrects for the glomerular filtration of 99mTc MDP. Using this method, which only requires a .gamma. counter, significant differences from normal controls were shown in patients with osteomalacia, renal osteodystrophy, Paget''s disease and hypercalcemia. The method provides routine on quantitative data to add to the imaging information in th bone scan.