Inhibitors of pyrimidine biosynthesis. Part 1. Synthesis of potential transition-state analogues of aspartate transcarbamylase
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 2721-2727
- https://doi.org/10.1039/p19800002721
Abstract
A systematic variation of the structure of a transition-state analogue of aspartate transcarbamylase has been carried out. A new, and general, synthesis of these analogues, starting from the appropriate amino-acid is described.This publication has 3 references indexed in Scilit:
- EFFECTS OF N-(PHOSPHONACETYL)-L-ASPARTATE ON MURINE TUMORS AND NORMAL TISSUES INVIVO AND INVITRO AND RELATIONSHIP OF SENSITIVITY TO RATE OF PROLIFERATION AND LEVEL OF ASPARTATE-TRANSCARBAMYLASE1978
- Synthesis of DL-2,3-diacyloxypropylphosphonylcholines from DL-2,3-diacyloxyiodopropanesChemistry and Physics of Lipids, 1976
- ANTITUMOR ACTIVITY OF N-(PHOSPHONACETYL)-L-ASPARTIC ACID, A TRANSITION-STATE INHIBITOR OF ASPARTATE-TRANSCARBAMYLASE1976