Serum and Urinary Amino Acids in Normouricemic and Hyperuricemic Subjects
- 1 April 1965
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 62 (4) , 658-666
- https://doi.org/10.7326/0003-4819-62-4-658
Abstract
There are potentially two main causes of the hyperuricemia in gout—underexcretion of uric acid and overproduction of uric acid. Underexcretion can occur either in the gastrointestinal tract or in the kidney. Sorensen (1) has shown that uric acid destruction by bacterial flora of the gastrointestinal tract is not decreased and may even be increased in gouty subjects. Underexcretion of uric acid in the kidney, however, has been demonstrated in some gouty individuals (2, 3). These patients had decreased clearance of endogenous uric acid when all other parameters of renal function were normal. Inability of the gouty patient to excrete normalKeywords
This publication has 1 reference indexed in Scilit:
- Renal Excretion of Urate in Patients With GoutArchives of internal medicine (1960), 1964