Reproducibility of the measurement of ciprofloxacin concentration in bronchial mucosa
- 1 March 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 27 (3) , 329-333
- https://doi.org/10.1093/jac/27.3.329
Abstract
The reproducibility of ciprofloxacin estimations was investigated in duplicate samples of bronchial mucosa from patients undergoing fibreoptic bronchoscopy. At the time of biopsy, venous blood was collected from each patient. Between 3.5 and 5.0 h after dosing, penetration (%) into the mucosa was 162.13 (S.D. 19.77). The correlation coefficient (Pearson's) between duplicate samples was 0.93. The confidence limits (95%) for a single measurement were ±1.47 mg/kg.Keywords
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