In Vitro Reactivity in Allograft Tolerance: Persistence of Mixed Leukocyte Culture Reactivity in Highly Tolerant Rats
Open Access
- 1 October 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (4) , 1538-1541
- https://doi.org/10.4049/jimmunol.119.4.1538
Abstract
Mixed leukocyte culture reactivity was studied in adult W/Fu rats judged to be highly tolerant after the inoculation of (W/Fu × BN)F1 hybrid spleen and bone marrow cells at birth. Reactivity was observed in a majority of tolerant donors tested and documented by quantitative dose-response and kinetic studies. Allograft tolerance cannot be explained by a complete lack of specific immune reactivity to tolerated alloantigens.This publication has 0 references indexed in Scilit: