Pathogenesis and treatment of renal dysfunction in rhabdomyolysis
- 12 April 2001
- journal article
- review article
- Published by Springer Nature in Intensive Care Medicine
- Vol. 27 (5) , 803-811
- https://doi.org/10.1007/s001340100878
Abstract
Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction. Renal failure is due to renal vasoconstriction, tubular damage caused by oxidant injury, and possibly tubular obstruction. Recent studies have provided greater insight into the rationale behind current therapy and potential treatment strategies. This review thus aims to summarise current understanding of the causes, pathogenesis and treatment of renal failure caused by rhabdomyolysis.Keywords
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